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Methods Used by US Adults to Stop Smoking Cigarettes, 2020–2022

Foxon F. Niaura R. CDC’s nationally-representative US health survey data (NHIS) asked US adults who stopped smoking completely from 2020–2022 which methods they used to stop. 7.5 million US adults stopped smoking completely from 2020–2022. 54.6% (4.1 million adults) used one or more nicotine products to stop smoking completely from 2020–2022. 42.5% (3.2 million) used… Read More

Data

Rising Uptake of Alternative Nicotine Products (ANPs) by Smoking-Naïve Individuals Is Not Necessarily a Threat to Public Health: The Case of Diversion by Snus in Norway

Selya A and Lund KE. Background: Adults who smoke tobacco can benefit by switching to less-harmful alternative nicotine products (ANPs). However, ANP uptake by smoking-naïve people is a concern. Several publications have reported increasing rates of ANP use by smoking-naïve individuals. However, these concerns seems at odds with historic declines in tobacco smoking in many… Read More

Prescription Medicines

Nonclinical Studies of Abuse Potential With Dual Orexin Receptor Antagonists: Concordance With Real-World Use

Authors: Moline M, Cheng JY, Henningfield J, Sembower M, Pype S, Buchhalter AR Background: Drugs acting on the central nervous system are subject to a determination of abuse potential prior to regulatory approval in the United States (US). Since the dual orexin antagonists (DORAs) are hypnotics, each approved drug (lemborexant, suvorexant, daridorexant) underwent a comprehensive… Read More

Prescription Medicines

No Indication of Abuse or Withdrawal Potential with Esmethadone (REL-1017): Results From Two Phase 3 Randomized Placebo-Controlled Trials in Patients With Major Depressive Disorder

Pappagallo M, Shram M, Henningfield J, Gorodetsky C, De Martin S, Vocci F, Sapienza F, Kosten T, Guidetti C, O’Gorman C, Folli F, Traversa S, Inturrisi C, Manfredi P Background: Esmethadone (REL-1017) is a promising adjunctive antidepressant candidate currently in Phase 3 development as an N-methyl-D-aspartate receptor uncompetitive antagonist. It is the dextro-isomer of racemic… Read More

What Will It Take to Move the Harm Reduction Debate Forward?

Poster #160 Authors: Gitchell J Abstract: Background: The role of explicit harm reduction approaches to tobacco smoking has been debated for decades. From the historical deception of reportedly low-tar filtered cigarettes versus actual low-toxin exposure smokeless tobacco and snus, to the current focus around e-cigarettes and other noncombustible tobacco and nicotine products, the issues and… Read More

Counterfactual Trend Modeling to Examine How Youth Smoking Trends Changed during the E-Cigarette Era

Poster #159 Authors: Selya A, Foxon F Abstract: A major concern about e-cigarettes is that they may act as a gateway to cigarette smoking – the most harmful tobacco product – among youth; however, while there is clearly an association between e-cigarette use and smoking among youth, growing evidence supports that the association is not… Read More

What Substances are Adolescents Vaping? Estimating Nicotine-Specific and Marijuana-Specific Vaping from US National Surveys

Poster #158 Authors: Selya A, Kim S, Shiffman S, Gitchell JG, Foxon F Abstract: Background: The prevalence of electronic cigarette (“e-cigarettes”) use among youth has raised alarm over recent years. Vaping is usually assumed to be of nicotine, but uncertainties in survey definitions may also include non-nicotine substances which can impose different risks (particularly marijuana)…. Read More

Updated Population-Level Counterfactual Trend Modelling to Examine the Relationship between Smoking Prevalence and E-Cigarette Use among US Adults and Adolescents

Poster #135 Author: Foxon F Abstract: Background Concerns have arisen that e-cigarettes (ECs) may act as a gateway to combustible cigarettes (CC) among adolescents and may not facilitate switching away from CCs among adults. Population-level trend studies examine whether smoking prevalence consistent with those concerns is observed. Previous US analyses (Foxon & Selya 2020; Foxon… Read More